Assay Detail
Functional
CHEMBL4714988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Activin A-induced Smad3 phosphorylation in human Epi293F cells pretreated for 10 mins followed by addition of TGF-beta1 measured after 120 mins by AlphaLISA assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Epi293F |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.40 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744618 | — | — | 1 | 6.41 |
| CHEMBL4758580 | — | — | 1 | 6.37 |
| CHEMBL4752410 | — | — | 1 | 6.28 |
| CHEMBL4764221 | — | — | 1 | 6.20 |
| CHEMBL4791414 | — | — | 1 | 6.06 |
| CHEMBL4747422 | — | — | 1 | 6.04 |
| CHEMBL4792464 | — | — | 1 | 5.66 |
| CHEMBL4751832 | — | — | 1 | 5.54 |
| CHEMBL4747912 | — | — | 1 | 5.48 |
| CHEMBL4741913 | — | — | 1 | 5.39 |
| CHEMBL4752199 | — | — | 1 | 5.32 |
| CHEMBL4750258 | — | — | 1 | 5.12 |
| CHEMBL4779273 | — | — | 1 | 5.04 |
| CHEMBL4741185 | — | — | 1 | 4.96 |
| CHEMBL4748097 | — | — | 1 | 4.92 |
| CHEMBL4744988 | — | — | 1 | 4.92 |
| CHEMBL4764416 | — | — | 1 | 4.92 |
| CHEMBL4795223 | — | — | 1 | 4.85 |
| CHEMBL4749061 | — | — | 1 | 4.82 |
| CHEMBL4779579 | — | — | 1 | 4.66 |
| CHEMBL4798505 | — | — | 1 | 4.54 |
| CHEMBL4792978 | — | — | 1 | - |
| CHEMBL4787891 | — | — | 1 | - |
| CHEMBL4749011 | — | — | 1 | - |
| CHEMBL4763627 | — | — | 1 | - |
| CHEMBL4782729 | — | — | 1 | - |
| CHEMBL4763122 | — | — | 1 | - |
| CHEMBL4777071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744618 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4758580 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4752410 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4764221 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4791414 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4747422 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4792464 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4751832 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4747912 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4741913 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4752199 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4750258 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4779273 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4741185 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4748097 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4744988 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4764416 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4795223 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4749061 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4779579 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4798505 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4792978 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL4787891 | — | IC50 | > | 1300.0 | nM | - |
| CHEMBL4749011 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL4763627 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL4782729 | — | IC50 | > | 38000.0 | nM | - |
| CHEMBL4763122 | — | IC50 | > | 3800.0 | nM | - |
| CHEMBL4777071 | — | IC50 | > | 3800.0 | nM | - |