Assay Detail
Binding
CHEMBL4715096
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Inhibition of COX1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.55 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | 4.0 | 1 | 8.85 |
| CHEMBL3427203 | — | — | 1 | 8.30 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.46 |
| CHEMBL3357103 | — | — | 1 | 6.32 |
| CHEMBL1235806 | — | — | 1 | 4.75 |
| CHEMBL28527 | MAVACOXIB | 2.0 | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3427203 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL25 | ASPIRIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3357103 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1235806 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL28527 | MAVACOXIB | IC50 | = | 25500.0 | nM | 4.59 |