Assay Detail
Binding
CHEMBL4715101
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Inhibition of COX1 in human OVCAR-3 cells assessed as reduction in PGE2 level incubated for 30 mins by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.94 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26915 | SC-560 | — | 1 | 8.10 |
| CHEMBL4800072 | — | — | 1 | 7.16 |
| CHEMBL4784073 | — | — | 1 | 7.05 |
| CHEMBL4797035 | — | — | 1 | 6.40 |
| CHEMBL4758829 | — | — | 1 | 6.05 |
| CHEMBL4788232 | — | — | 1 | 5.96 |
| CHEMBL4745938 | — | — | 1 | 5.30 |
| CHEMBL4755592 | — | — | 1 | 5.27 |
| CHEMBL4757602 | — | — | 1 | 5.24 |
| CHEMBL4761793 | — | — | 1 | 4.69 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26915 | SC-560 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4800072 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4784073 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4797035 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4758829 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4788232 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4745938 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4755592 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4757602 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4761793 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL118 | CELECOXIB | IC50 | = | 80900.0 | nM | 4.09 |