Assay Detail
Binding
CHEMBL4715587
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Inhibition of F-Bak binding to GST-tagged BCL-XL (unknown origin) measured after 1 hr by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of A-1293102, a Potent and Selective BCL-X Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.61 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3699066 | — | — | 1 | 9.85 |
| CHEMBL3699067 | — | — | 1 | 9.37 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3699066 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3699067 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL443684 | NAVITOCLAX | Ki | < | 0.1 | nM | - |