Assay Detail
Binding
CHEMBL4716067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length N-terminal polyHis-tagged PI3K p110beta/p85alpha (unknown origin) expressed in baculovirus infected Sf9 cells using PIP2 as substrate in presence of ATP incubated for 20 mins by Alphascreen assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.51 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747926 | — | — | 1 | 7.52 |
| CHEMBL2171931 | — | — | 1 | 7.11 |
| CHEMBL4780867 | — | — | 1 | 6.35 |
| CHEMBL4762294 | — | — | 1 | 6.29 |
| CHEMBL4790186 | — | — | 1 | 6.27 |
| CHEMBL2216895 | — | — | 1 | 5.97 |
| CHEMBL4763849 | — | — | 1 | 5.75 |
| CHEMBL4754382 | — | — | 1 | 5.63 |
| CHEMBL4784595 | — | — | 1 | 5.45 |
| CHEMBL4788529 | — | — | 1 | 5.45 |
| CHEMBL4756034 | — | — | 1 | 5.26 |
| CHEMBL4747799 | — | — | 1 | 5.23 |
| CHEMBL4800111 | — | — | 1 | 5.05 |
| CHEMBL4761860 | — | — | 1 | 4.98 |
| CHEMBL4745140 | — | — | 1 | 4.85 |
| CHEMBL4744888 | — | — | 1 | 4.74 |
| CHEMBL4756545 | — | — | 1 | 4.73 |
| CHEMBL4798019 | — | — | 1 | 4.61 |
| CHEMBL4740720 | — | — | 1 | 4.52 |
| CHEMBL4763925 | — | — | 1 | 4.50 |
| CHEMBL4759169 | — | — | 1 | - |
| CHEMBL4784596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747926 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2171931 | — | IC50 | = | 78.6 | nM | 7.11 |
| CHEMBL4780867 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4762294 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4790186 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2216895 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4763849 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4754382 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4784595 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4788529 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL4756034 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL4747799 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL4800111 | — | IC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL4761860 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4745140 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4744888 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4756545 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4798019 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4740720 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4763925 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL4759169 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL4784596 | — | IC50 | > | 125000.0 | nM | - |