Assay Detail
Binding
CHEMBL4716150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of ES2 from recombinant human ER-beta incubated for 2 hrs by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.80 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777271 | — | — | 1 | 7.39 |
| CHEMBL4753594 | — | — | 1 | 7.25 |
| CHEMBL4780337 | — | — | 1 | 7.13 |
| CHEMBL4755831 | — | — | 1 | 6.53 |
| CHEMBL149791 | — | — | 1 | 6.51 |
| CHEMBL4749692 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777271 | — | EC50 | = | 40.9 | nM | 7.39 |
| CHEMBL4753594 | — | EC50 | = | 56.3 | nM | 7.25 |
| CHEMBL4780337 | — | EC50 | = | 73.6 | nM | 7.13 |
| CHEMBL4755831 | — | EC50 | = | 296.0 | nM | 6.53 |
| CHEMBL149791 | — | EC50 | = | 307.0 | nM | 6.51 |
| CHEMBL4749692 | — | EC50 | = | 1080.0 | nM | 5.97 |