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Assay Detail

CHEMBL4717199

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Functional
Cytotoxicity against human MES-SA cells transfected with mCherry fluorescent protein assessed as inhibition of cell proliferation incubated for 72 hrs by fluorescent assay
ChEMBL ↗
81
Total Activities
50
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MES-SA
Confidence 1 — Organism
Curated By Autocuration

Target

MES-SA (CHEMBL614343) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance.
Pape VF,Tóth S,Füredi A,Szebényi K,Lovrics A,Szabó P,Wiese M,Szakács G
Eur J Med Chem (2016) 117 : 335 -354
PubMed 27161177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 79 5.77 7.53
pIC50 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1631724 — — 2 7.53
CHEMBL1631725 — — 2 7.50
CHEMBL4755712 — — 2 7.49
CHEMBL1631726 — — 2 7.38
CHEMBL4776481 — — 2 7.11
CHEMBL4743024 — — 1 7.02
CHEMBL4760307 — — 2 6.92
CHEMBL3250265 — — 2 6.64
CHEMBL4789856 — — 2 6.62
CHEMBL4759207 — — 2 6.58
CHEMBL4761397 — — 2 6.54
CHEMBL4760526 — — 2 6.32
CHEMBL4754848 — — 2 6.27
CHEMBL4584496 — — 2 6.16
CHEMBL4788932 — — 2 6.12
CHEMBL4757610 — — 2 6.11
CHEMBL4795083 — — 2 6.08
CHEMBL231616 TRIAPINE 3.0 1 5.88
CHEMBL4747797 — — 1 5.84
CHEMBL4755683 — — 1 5.63
CHEMBL4756990 — — 2 5.63
CHEMBL4794774 — — 2 5.57
CHEMBL4785334 — — 1 5.57
CHEMBL2004141 — — 2 5.57
CHEMBL2285982 — — 1 5.48
CHEMBL3325577 — — 2 5.42
CHEMBL4791886 — — 2 5.37
CHEMBL1996879 — — 2 5.33
CHEMBL4756801 — — 1 5.29
CHEMBL522087 — — 1 5.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1631724 — IC50 = 29.51 nM 7.53
CHEMBL1631724 — IC50 = 30.0 nM 7.52
CHEMBL1631725 — IC50 = 31.62 nM 7.50
CHEMBL1631725 — IC50 = 32.0 nM 7.50
CHEMBL4755712 — IC50 = 32.36 nM 7.49
CHEMBL4755712 — IC50 = 33.0 nM 7.48
CHEMBL1631726 — IC50 = 41.69 nM 7.38
CHEMBL1631726 — IC50 = 65.0 nM 7.19
CHEMBL4776481 — IC50 = 77.62 nM 7.11
CHEMBL4743024 — IC50 = 96.0 nM 7.02
CHEMBL4776481 — IC50 = 102.0 nM 6.99
CHEMBL4760307 — IC50 = 120.23 nM 6.92
CHEMBL4760307 — IC50 = 130.0 nM 6.89
CHEMBL3250265 — IC50 = 229.09 nM 6.64
CHEMBL4789856 — IC50 = 239.88 nM 6.62
CHEMBL4789856 — IC50 = 250.0 nM 6.60
CHEMBL3250265 — IC50 = 250.0 nM 6.60
CHEMBL4759207 — IC50 = 260.0 nM 6.58
CHEMBL4761397 — IC50 = 288.4 nM 6.54
CHEMBL4761397 — IC50 = 300.0 nM 6.52
CHEMBL4759207 — IC50 = 338.84 nM 6.47
CHEMBL4760526 — IC50 = 478.63 nM 6.32
CHEMBL4760526 — IC50 = 480.0 nM 6.32
CHEMBL4754848 — IC50 = 537.03 nM 6.27
CHEMBL4754848 — IC50 = 560.0 nM 6.25
CHEMBL4584496 — IC50 = 691.83 nM 6.16
CHEMBL4584496 — IC50 = 720.0 nM 6.14
CHEMBL4788932 — IC50 = 758.58 nM 6.12
CHEMBL4757610 — IC50 = 776.25 nM 6.11
CHEMBL4788932 — IC50 = 790.0 nM 6.10
CHEMBL4757610 — IC50 = 820.0 nM 6.09
CHEMBL4795083 — IC50 = 831.76 nM 6.08
CHEMBL4795083 — IC50 = 850.0 nM 6.07
CHEMBL231616 TRIAPINE IC50 = 1305.0 nM 5.88
CHEMBL4747797 — IC50 = 1440.0 nM 5.84
CHEMBL4755683 — IC50 = 2330.0 nM 5.63
CHEMBL4756990 — IC50 = 2344.23 nM 5.63
CHEMBL4756990 — IC50 = 2450.0 nM 5.61
CHEMBL4785334 — IC50 = 2670.0 nM 5.57
CHEMBL2004141 — IC50 = 2700.0 nM 5.57
CHEMBL2004141 — IC50 = 2691.53 nM 5.57
CHEMBL4794774 — IC50 = 2691.53 nM 5.57
CHEMBL4794774 — IC50 = 2740.0 nM 5.56
CHEMBL2285982 — IC50 = 3340.0 nM 5.48
CHEMBL3325577 — IC50 = 3801.89 nM 5.42
CHEMBL3325577 — IC50 = 4070.0 nM 5.39
CHEMBL4791886 — IC50 = 4260.0 nM 5.37
CHEMBL4791886 — IC50 = 4265.8 nM 5.37
CHEMBL1996879 — IC50 = 4720.0 nM 5.33
CHEMBL1996879 — IC50 = 4677.35 nM 5.33