Assay Detail
Functional
CHEMBL4717271
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Cytotoxicity against human HeLa S3 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa S3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.74 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412190 | APLYRONINE A | — | 1 | 11.00 |
| CHEMBL4754742 | — | — | 1 | 10.02 |
| CHEMBL264271 | APLYRONINE C | — | 1 | 7.77 |
| CHEMBL4760181 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412190 | APLYRONINE A | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4754742 | — | IC50 | = | 0.096 | nM | 10.02 |
| CHEMBL264271 | APLYRONINE C | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4760181 | — | IC50 | = | 700.0 | nM | 6.16 |