Assay Detail
ADMET
CHEMBL4717675
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Inhibition of calcium-induced contraction in K+-depolarized guinea pig longitudinal smooth muscle
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.01 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764860 | — | — | 1 | 5.44 |
| CHEMBL1200606 | MEXILETINE HYDROCHLORIDE | 4.0 | 1 | 5.07 |
| CHEMBL4741603 | — | — | 1 | 4.97 |
| CHEMBL4742143 | — | — | 1 | 4.86 |
| CHEMBL4746834 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764860 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1200606 | MEXILETINE HYDROCHLORIDE | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4741603 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4742143 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4746834 | — | IC50 | = | 19600.0 | nM | 4.71 |