Assay Detail
Functional
CHEMBL4718405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxic activities of novel 2,5-diketopiperazine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.46 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 7.83 |
| CHEMBL4787043 | — | — | 1 | 6.30 |
| CHEMBL4799044 | — | — | 1 | 6.05 |
| CHEMBL4780890 | — | — | 1 | 5.70 |
| CHEMBL4797507 | — | — | 1 | 5.47 |
| CHEMBL4796022 | — | — | 1 | 5.47 |
| CHEMBL4747045 | — | — | 1 | 5.28 |
| CHEMBL4792497 | — | — | 1 | 5.21 |
| CHEMBL4743607 | — | — | 1 | 4.97 |
| CHEMBL4798793 | — | — | 1 | 4.87 |
| CHEMBL4740826 | — | — | 1 | 4.69 |
| CHEMBL4795367 | — | — | 1 | 4.58 |
| CHEMBL4743751 | — | — | 1 | 4.55 |
| CHEMBL4783249 | — | — | 1 | - |
| CHEMBL4752725 | — | — | 1 | - |
| CHEMBL4747762 | — | — | 1 | - |
| CHEMBL4793845 | — | — | 1 | - |
| CHEMBL4760184 | — | — | 1 | - |
| CHEMBL4751796 | — | — | 1 | - |
| CHEMBL4755984 | — | — | 1 | - |
| CHEMBL4740869 | — | — | 1 | - |
| CHEMBL4776511 | — | — | 1 | - |
| CHEMBL4764631 | — | — | 1 | - |
| CHEMBL4790881 | — | — | 1 | - |
| CHEMBL4757919 | — | — | 1 | - |
| CHEMBL4755789 | — | — | 1 | - |
| CHEMBL4763218 | — | — | 1 | - |
| CHEMBL4753728 | — | — | 1 | - |
| CHEMBL4789370 | — | — | 1 | - |
| CHEMBL4763118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096380 | PLINABULIN | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL4787043 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4799044 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4780890 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4797507 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4796022 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4747045 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4792497 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4743607 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4798793 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4740826 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL4795367 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL4743751 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL3633234 | — | IC50 | - | — | - | |
| CHEMBL4747119 | — | IC50 | - | — | - | |
| CHEMBL4757025 | — | IC50 | - | — | - | |
| CHEMBL4800496 | — | IC50 | - | — | - | |
| CHEMBL4783733 | — | IC50 | - | — | - | |
| CHEMBL4760529 | — | IC50 | - | — | - | |
| CHEMBL4783249 | — | IC50 | - | — | - | |
| CHEMBL4752725 | — | IC50 | - | — | - | |
| CHEMBL4747762 | — | IC50 | - | — | - | |
| CHEMBL4793845 | — | IC50 | - | — | - | |
| CHEMBL4760184 | — | IC50 | - | — | - | |
| CHEMBL4751796 | — | IC50 | - | — | - | |
| CHEMBL4755984 | — | IC50 | - | — | - | |
| CHEMBL4740869 | — | IC50 | - | — | - | |
| CHEMBL4776511 | — | IC50 | - | — | - | |
| CHEMBL4764631 | — | IC50 | - | — | - | |
| CHEMBL4790881 | — | IC50 | - | — | - | |
| CHEMBL4757919 | — | IC50 | - | — | - | |
| CHEMBL4755789 | — | IC50 | - | — | - | |
| CHEMBL4763218 | — | IC50 | - | — | - | |
| CHEMBL4753728 | — | IC50 | - | — | - | |
| CHEMBL4789370 | — | IC50 | - | — | - | |
| CHEMBL4763118 | — | IC50 | - | — | - |