Assay Detail
Functional
CHEMBL4718608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antioxidant activity in human SH-SY5Y cells assessed as inhibition of H2O2-induced DCFH oxidation measured after 1 hr by DCFH-DA dye based fluorescence assay
32
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 16 | - | - |
| IC50 | 16 | 4.33 | 4.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747699 | — | — | 2 | 4.67 |
| CHEMBL4755403 | — | — | 2 | 4.66 |
| CHEMBL4747354 | — | — | 2 | 4.49 |
| CHEMBL4793012 | — | — | 2 | 4.45 |
| CHEMBL4740326 | — | — | 2 | 4.38 |
| CHEMBL4744769 | — | — | 2 | 4.36 |
| CHEMBL4793596 | — | — | 2 | 4.35 |
| CHEMBL4760848 | — | — | 2 | 4.30 |
| CHEMBL4793823 | — | — | 2 | 4.30 |
| CHEMBL4799132 | — | — | 2 | 4.15 |
| CHEMBL4797546 | — | — | 2 | 4.11 |
| CHEMBL153 | TROLOX | — | 2 | 4.08 |
| CHEMBL4763677 | — | — | 2 | 4.03 |
| CHEMBL4744943 | — | — | 2 | - |
| CHEMBL4790338 | — | — | 2 | - |
| CHEMBL4756734 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747699 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4755403 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4747354 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL4793012 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL4740326 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL4744769 | — | IC50 | = | 43800.0 | nM | 4.36 |
| CHEMBL4793596 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL4793823 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4760848 | — | IC50 | = | 50300.0 | nM | 4.30 |
| CHEMBL4799132 | — | IC50 | = | 71200.0 | nM | 4.15 |
| CHEMBL4797546 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL153 | TROLOX | IC50 | = | 82300.0 | nM | 4.08 |
| CHEMBL4763677 | — | IC50 | = | 92600.0 | nM | 4.03 |
| CHEMBL4747699 | — | Activity | - | — | - | |
| CHEMBL4747354 | — | Activity | - | — | - | |
| CHEMBL4755403 | — | Activity | - | — | - | |
| CHEMBL153 | TROLOX | Activity | - | — | - | |
| CHEMBL4744943 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4763677 | — | Activity | - | — | - | |
| CHEMBL4744769 | — | Activity | - | — | - | |
| CHEMBL4790338 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL4740326 | — | Activity | - | — | - | |
| CHEMBL4793823 | — | Activity | - | — | - | |
| CHEMBL4756734 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4756734 | — | Activity | - | — | - | |
| CHEMBL4799132 | — | Activity | - | — | - | |
| CHEMBL4797546 | — | Activity | - | — | - | |
| CHEMBL4790338 | — | Activity | - | — | - | |
| CHEMBL4793012 | — | Activity | - | — | - | |
| CHEMBL4760848 | — | Activity | - | — | - | |
| CHEMBL4744943 | — | Activity | - | — | - | |
| CHEMBL4793596 | — | Activity | - | — | - |