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Assay Detail

CHEMBL4718732

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells assessed as reduction in cell viability by alamar blue dye based fluorimetry analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.
Papadopoulou MV,Bloomer WD,Rosenzweig HS,Wilkinson SR,Szular J,Kaiser M
Eur J Med Chem (2016) 123 : 895 -904
PubMed 27543881 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.40 4.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4217594 1 4.76
CHEMBL4209908 1 4.63
CHEMBL3612338 1 4.54
CHEMBL4206147 1 4.50
CHEMBL4213380 1 4.44
CHEMBL4202551 1 4.40
CHEMBL3612341 1 4.34
CHEMBL3612344 1 4.17
CHEMBL3612339 1 4.15
CHEMBL3612337 1 4.04
CHEMBL4795543 1 -
CHEMBL4755856 1 -
CHEMBL2070676 1 -
CHEMBL4743037 1 -
CHEMBL4206018 1 -
CHEMBL3410620 1 -
CHEMBL4209271 1 -
CHEMBL4764607 1 -
CHEMBL4762984 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4217594 IC50 = 17300.0 nM 4.76
CHEMBL4209908 IC50 = 23400.0 nM 4.63
CHEMBL3612338 IC50 = 28900.0 nM 4.54
CHEMBL4206147 IC50 = 31600.0 nM 4.50
CHEMBL4213380 IC50 = 36200.0 nM 4.44
CHEMBL4202551 IC50 = 40200.0 nM 4.40
CHEMBL3612341 IC50 = 45300.0 nM 4.34
CHEMBL3612344 IC50 = 68400.0 nM 4.17
CHEMBL3612339 IC50 = 70400.0 nM 4.15
CHEMBL3612337 IC50 = 92000.0 nM 4.04
CHEMBL4795543 IC50 = 230000.0 nM -
CHEMBL4755856 IC50 = 254000.0 nM -
CHEMBL2070676 IC50 = 129000.0 nM -
CHEMBL4743037 IC50 = 189000.0 nM -
CHEMBL4206018 IC50 = 112000.0 nM -
CHEMBL3410620 IC50 = 164700.0 nM -
CHEMBL4209271 IC50 > 289000.0 nM -
CHEMBL4764607 IC50 = 201000.0 nM -
CHEMBL4762984 IC50 = 179000.0 nM -