Assay Detail
Functional
CHEMBL4718765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes incubated for 72 hrs by resazurin dye based fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.67 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3800137 | — | — | 1 | 7.34 |
| CHEMBL1872842 | — | — | 1 | 7.11 |
| CHEMBL3797262 | — | — | 1 | 6.68 |
| CHEMBL4758947 | — | — | 1 | 6.66 |
| CHEMBL1459740 | — | — | 1 | 6.38 |
| CHEMBL2094559 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3800137 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1872842 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3797262 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4758947 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1459740 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2094559 | — | IC50 | = | 1500.0 | nM | 5.82 |