Assay Detail
Functional
CHEMBL4718827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse Ba/F3 cells expressing EGFR-L858R mutant assessed as inhibition of cell growth incubated for 48 hrs by XTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.92 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4786776 | — | — | 1 | 7.12 |
| CHEMBL4784258 | — | — | 1 | 7.11 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.06 |
| CHEMBL4759003 | — | — | 1 | 7.05 |
| CHEMBL4776396 | — | — | 1 | 7.01 |
| CHEMBL4760328 | — | — | 1 | 7.00 |
| CHEMBL4780286 | — | — | 1 | 6.90 |
| CHEMBL4783569 | — | — | 1 | 6.87 |
| CHEMBL4748367 | — | — | 1 | 6.85 |
| CHEMBL4789027 | — | — | 1 | 6.80 |
| CHEMBL4742081 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4786776 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4784258 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4759003 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4776396 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4760328 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4780286 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4783569 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4748367 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4789027 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4742081 | — | IC50 | = | 396.0 | nM | 6.40 |