Assay Detail
Binding
CHEMBL4718840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin) using Tyr 04 peptide as substrate incubated for 1 hr by Z'-LYTE assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.48 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4164805 | — | — | 1 | 9.70 |
| CHEMBL4175024 | — | — | 1 | 9.70 |
| CHEMBL4780286 | — | — | 1 | 9.40 |
| CHEMBL4783569 | — | — | 1 | 9.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4164805 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4175024 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4780286 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4783569 | — | IC50 | = | 0.8 | nM | 9.10 |