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Assay Detail

CHEMBL4718917

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mushroom tyrosinase using L-DOPA as substrate measured for 15 mins by UV-vis spectrophotometry
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Mushroom tyrosinase (CHEMBL6066154)
Type PROTEIN FAMILY
Organism Agaricus bisporus

Publication

ArgTX-636, a polyamine isolated from spider venom: A novel class of melanogenesis inhibitors.
Verdoni M,Roudaut H,De Pomyers H,Gigmes D,Bertin D,Luis J,Bengeloune AH,Mabrouk K
Bioorg Med Chem (2016) 24 : 5685 -5692
PubMed 27647371 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.08 5.08
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1098240 2 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1098240 IC50 = 8340.0 nM 5.08
CHEMBL1098240 Inhibition - % -