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Assay Detail

CHEMBL4718919

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Mixed type inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibitory constant measured for 15 mins by UV-vis spectrophotometry based Line-weaver Burk plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Mushroom tyrosinase (CHEMBL6066154)
Type PROTEIN FAMILY
Organism Agaricus bisporus

Publication

ArgTX-636, a polyamine isolated from spider venom: A novel class of melanogenesis inhibitors.
Verdoni M,Roudaut H,De Pomyers H,Gigmes D,Bertin D,Luis J,Bengeloune AH,Mabrouk K
Bioorg Med Chem (2016) 24 : 5685 -5692
PubMed 27647371 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.97 4.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1098240 1 4.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1098240 Ki = 10770.0 nM 4.97