Assay Detail
Binding
CHEMBL4719111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AChE (unknown origin) using acetylthiocholine chloride as substrate preincubated with enzyme for 15 mins followed by substrate addition by Ellman's method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.85 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752440 | — | — | 1 | 5.96 |
| CHEMBL4747183 | — | — | 1 | 5.94 |
| CHEMBL4794820 | — | — | 1 | 5.67 |
| CHEMBL4797045 | — | — | 1 | 5.18 |
| CHEMBL4760400 | — | — | 1 | 5.15 |
| CHEMBL4754607 | — | — | 1 | 5.00 |
| CHEMBL4800067 | — | — | 1 | 4.95 |
| CHEMBL4761620 | — | — | 1 | 4.91 |
| CHEMBL4754171 | — | — | 1 | 4.89 |
| CHEMBL4757955 | — | — | 1 | 4.78 |
| CHEMBL4789991 | — | — | 1 | 4.72 |
| CHEMBL4797884 | — | — | 1 | 4.71 |
| CHEMBL4739877 | — | — | 1 | 4.70 |
| CHEMBL4788300 | — | — | 1 | 4.70 |
| CHEMBL4791084 | — | — | 1 | 4.70 |
| CHEMBL4763528 | — | — | 1 | 4.67 |
| CHEMBL4743869 | — | — | 1 | 4.67 |
| CHEMBL4744408 | — | — | 1 | 4.65 |
| CHEMBL4791351 | — | — | 1 | 4.63 |
| CHEMBL4780172 | — | — | 1 | 4.62 |
| CHEMBL4799570 | — | — | 1 | 4.61 |
| CHEMBL4755928 | — | — | 1 | 4.57 |
| CHEMBL4756742 | — | — | 1 | 4.55 |
| CHEMBL4740786 | — | — | 1 | 4.55 |
| CHEMBL4748587 | — | — | 1 | 4.48 |
| CHEMBL4762214 | — | — | 1 | 4.46 |
| CHEMBL4797575 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752440 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4747183 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4794820 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4797045 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4760400 | — | IC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL4754607 | — | IC50 | = | 10110.0 | nM | 5.00 |
| CHEMBL4800067 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL4761620 | — | IC50 | = | 12240.0 | nM | 4.91 |
| CHEMBL4754171 | — | IC50 | = | 12860.0 | nM | 4.89 |
| CHEMBL4757955 | — | IC50 | = | 16480.0 | nM | 4.78 |
| CHEMBL4789991 | — | IC50 | = | 19120.0 | nM | 4.72 |
| CHEMBL4797884 | — | IC50 | = | 19480.0 | nM | 4.71 |
| CHEMBL4739877 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4788300 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4791084 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4763528 | — | IC50 | = | 21160.0 | nM | 4.67 |
| CHEMBL4743869 | — | IC50 | = | 21280.0 | nM | 4.67 |
| CHEMBL4744408 | — | IC50 | = | 22240.0 | nM | 4.65 |
| CHEMBL4791351 | — | IC50 | = | 23320.0 | nM | 4.63 |
| CHEMBL4780172 | — | IC50 | = | 24120.0 | nM | 4.62 |
| CHEMBL4799570 | — | IC50 | = | 24560.0 | nM | 4.61 |
| CHEMBL4755928 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL4756742 | — | IC50 | = | 28340.0 | nM | 4.55 |
| CHEMBL4740786 | — | IC50 | = | 28340.0 | nM | 4.55 |
| CHEMBL4748587 | — | IC50 | = | 33160.0 | nM | 4.48 |
| CHEMBL4762214 | — | IC50 | = | 34560.0 | nM | 4.46 |
| CHEMBL4797575 | — | IC50 | = | 38340.0 | nM | 4.42 |