Assay Detail
Binding
CHEMBL4719352
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Displacement of [125I]MIP-1alpha from CCR5 receptor in rhesus monkey membrane incubated for 120 mins by liquid scintillation counting analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.69 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 9.62 |
| CHEMBL4795179 | — | — | 1 | 6.82 |
| CHEMBL4748891 | — | — | 1 | 6.62 |
| CHEMBL4799343 | — | — | 1 | - |
| CHEMBL4761614 | — | — | 1 | - |
| CHEMBL4800480 | — | — | 1 | - |
| CHEMBL4761273 | — | — | 1 | - |
| CHEMBL4761986 | — | — | 1 | - |
| CHEMBL4797451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256907 | MARAVIROC | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL4795179 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL4748891 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL4799343 | — | Ki | - | — | - | |
| CHEMBL4761614 | — | Ki | - | — | - | |
| CHEMBL4800480 | — | Ki | - | — | - | |
| CHEMBL4761273 | — | Ki | - | — | - | |
| CHEMBL4761986 | — | Ki | - | — | - | |
| CHEMBL4797451 | — | Ki | - | — | - |