Assay Detail
Functional
CHEMBL4721177
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Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer glo luminescent cell viability assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.26 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745521 | — | — | 1 | 5.97 |
| CHEMBL4754811 | — | — | 1 | 5.61 |
| CHEMBL4750608 | — | — | 1 | 5.57 |
| CHEMBL4755444 | — | — | 1 | 5.42 |
| CHEMBL4756049 | — | — | 1 | 5.41 |
| CHEMBL4750196 | — | — | 1 | 5.27 |
| CHEMBL4777353 | — | — | 1 | 5.26 |
| CHEMBL4792426 | — | — | 1 | 5.16 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.14 |
| CHEMBL4796407 | — | — | 1 | 5.11 |
| CHEMBL4753193 | — | — | 1 | 4.90 |
| CHEMBL4790583 | — | — | 1 | 4.89 |
| CHEMBL4757724 | — | — | 1 | 4.71 |
| CHEMBL4749765 | — | — | 1 | - |
| CHEMBL4777554 | — | — | 1 | - |
| CHEMBL4782025 | — | — | 1 | - |
| CHEMBL4789811 | — | — | 1 | - |
| CHEMBL4790485 | — | — | 1 | - |
| CHEMBL4757531 | — | — | 1 | - |
| CHEMBL4747893 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745521 | — | IC50 | = | 1072.0 | nM | 5.97 |
| CHEMBL4754811 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4750608 | — | IC50 | = | 2675.0 | nM | 5.57 |
| CHEMBL4755444 | — | IC50 | = | 3826.0 | nM | 5.42 |
| CHEMBL4756049 | — | IC50 | = | 3856.0 | nM | 5.41 |
| CHEMBL4750196 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL4777353 | — | IC50 | = | 5489.0 | nM | 5.26 |
| CHEMBL4792426 | — | IC50 | = | 6997.0 | nM | 5.16 |
| CHEMBL939 | GEFITINIB | IC50 | = | 7184.0 | nM | 5.14 |
| CHEMBL4796407 | — | IC50 | = | 7811.0 | nM | 5.11 |
| CHEMBL4753193 | — | IC50 | = | 12649.0 | nM | 4.90 |
| CHEMBL4790583 | — | IC50 | = | 12876.0 | nM | 4.89 |
| CHEMBL4757724 | — | IC50 | = | 19482.0 | nM | 4.71 |
| CHEMBL4749765 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4777554 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4782025 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4789811 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4790485 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4757531 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4747893 | — | IC50 | > | 50000.0 | nM | - |