Assay Detail
Functional
CHEMBL4721179
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Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer glo luminescent cell viability assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.50 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752951 | — | — | 1 | 7.18 |
| CHEMBL4759414 | — | — | 1 | 6.97 |
| CHEMBL4755832 | — | — | 1 | 6.87 |
| CHEMBL4790655 | — | — | 1 | 6.84 |
| CHEMBL4776057 | — | — | 1 | 6.72 |
| CHEMBL4741678 | — | — | 1 | 6.66 |
| CHEMBL4743566 | — | — | 1 | 6.58 |
| CHEMBL4751768 | — | — | 1 | 6.48 |
| CHEMBL4760606 | — | — | 1 | 6.40 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.12 |
| CHEMBL4750608 | — | — | 1 | 6.05 |
| CHEMBL4754811 | — | — | 1 | 5.96 |
| CHEMBL4750196 | — | — | 1 | 5.63 |
| CHEMBL4789811 | — | — | 1 | - |
| CHEMBL4760864 | — | — | 1 | - |
| CHEMBL4782025 | — | — | 1 | - |
| CHEMBL4762998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752951 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4759414 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4755832 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4790655 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4776057 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4741678 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4743566 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL4751768 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL4760606 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL939 | GEFITINIB | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL4750608 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL4754811 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4750196 | — | IC50 | = | 2352.0 | nM | 5.63 |
| CHEMBL4789811 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4760864 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4782025 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4762998 | — | IC50 | > | 10000.0 | nM | - |