Assay Detail
Binding
CHEMBL4723095
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Inhibition of tyrosinase in neonatal human epidermal melanocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Melanocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.84 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66879 | COUMARIC ACID | — | 1 | 5.70 |
| CHEMBL146816 | METHYL P-HYDROXYCINNAMATE | — | 1 | 4.52 |
| CHEMBL202844 | N-TRANS-FERULOYLDOPAMINE | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66879 | COUMARIC ACID | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL146816 | METHYL P-HYDROXYCINNAMATE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL202844 | N-TRANS-FERULOYLDOPAMINE | IC50 | = | 50000.0 | nM | 4.30 |