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Assay Detail

CHEMBL4723100

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of mushroom tyrosinase using L-DOPA as substrate by dixon-plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Mushroom tyrosinase (CHEMBL6066154)
Type PROTEIN FAMILY
Organism Agaricus bisporus

Publication

Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Roulier B,Pérès B,Haudecoeur R
J Med Chem (2020) 63 : 13428 -13443
PubMed 32787103 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.75 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3898657 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3898657 Ki = 1800.0 nM 5.75