Assay Detail
Binding
CHEMBL4723109
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Inhibition of human HMV-II cell derived tyrosinase using DOPA as substrate incubated for 5 mins by light absorbance method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HMV-2 cell line |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.94 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43065 | OXYRESVERATROL | — | 1 | 5.12 |
| CHEMBL3343986 | — | — | 1 | 5.04 |
| CHEMBL2413822 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43065 | OXYRESVERATROL | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3343986 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2413822 | — | IC50 | = | 22000.0 | nM | 4.66 |