Assay Detail
Binding
CHEMBL4723119
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human tyrosinase expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.04 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66879 | COUMARIC ACID | — | 1 | 5.70 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.05 |
| CHEMBL4757912 | — | — | 1 | 5.00 |
| CHEMBL4759198 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66879 | COUMARIC ACID | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL165 | RESVERATROL | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4757912 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4759198 | — | IC50 | = | 40000.0 | nM | 4.40 |