Assay Detail
Binding
CHEMBL4723294
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Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.99 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284069 | — | — | 1 | 8.31 |
| CHEMBL3983290 | — | — | 1 | 8.02 |
| CHEMBL3973674 | — | — | 1 | 7.92 |
| CHEMBL3972276 | — | — | 1 | 7.89 |
| CHEMBL3940572 | — | — | 1 | 7.75 |
| CHEMBL3908044 | — | — | 1 | 7.66 |
| CHEMBL4106685 | — | — | 1 | 7.66 |
| CHEMBL3904499 | — | — | 1 | 7.66 |
| CHEMBL3973588 | — | — | 1 | 7.55 |
| CHEMBL4791610 | — | — | 1 | 7.48 |
| CHEMBL3916036 | — | — | 1 | 7.44 |
| CHEMBL4745615 | — | — | 1 | 7.41 |
| CHEMBL4752511 | — | — | 1 | 7.34 |
| CHEMBL4790514 | — | — | 1 | 7.18 |
| CHEMBL4787060 | — | — | 1 | 7.17 |
| CHEMBL3966721 | — | — | 1 | 7.14 |
| CHEMBL3828009 | LY-2874455 | 1.0 | 1 | 7.12 |
| CHEMBL4786195 | — | — | 1 | 7.10 |
| CHEMBL4758510 | — | — | 1 | 7.10 |
| CHEMBL3973808 | — | — | 1 | 7.09 |
| CHEMBL4781381 | — | — | 1 | 6.99 |
| CHEMBL3920470 | — | — | 1 | 6.99 |
| CHEMBL4754106 | — | — | 1 | 6.94 |
| CHEMBL4294665 | — | — | 1 | 6.86 |
| CHEMBL4780066 | — | — | 1 | 6.83 |
| CHEMBL3971213 | — | — | 1 | 6.77 |
| CHEMBL4789692 | — | — | 1 | 6.73 |
| CHEMBL4744460 | — | — | 1 | 6.71 |
| CHEMBL3954670 | — | — | 1 | 6.68 |
| CHEMBL3953738 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284069 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3983290 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL3973674 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3972276 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3940572 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3908044 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4106685 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3904499 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3973588 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4791610 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3916036 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4745615 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4752511 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4790514 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4787060 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3966721 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3828009 | LY-2874455 | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4786195 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4758510 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3973808 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4781381 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3920470 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4754106 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4294665 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4780066 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3971213 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4789692 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4744460 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL3954670 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL3953738 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL3977760 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL3957240 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL4785725 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL3929437 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL4777580 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL3969343 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL4778828 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL4779862 | — | IC50 | = | 573.0 | nM | 6.24 |
| CHEMBL1852688 | INFIGRATINIB | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL3905155 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL4752290 | — | IC50 | = | 1775.0 | nM | 5.75 |
| CHEMBL3971045 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3926134 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4277111 | — | IC50 | > | 3000.0 | nM | - |