Compound Detail
CHEMBL3977760
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Basic Information
| ChEMBL ID | CHEMBL3977760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ILTDXKXOGRYYPI-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
308.3
MW (Da)
1.54
ALogP
6
HBA
1
HBD
111.9
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.35 | 7.2325 | 45.0 | 4 |
| Fibroblast growth factor receptor 4 CHEMBL3839 | IC50 | 6.88 | 6.7 | 131.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 45.0 | nM | 7.35 | Biochemical Kinase Assay: Liquid handling and incubation steps were done on an I... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 45.0 | nM | 7.35 | Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKK... | 29541363 |
| Fibroblast growth factor receptor 4 | IC50 | = | 45.0 | nM | 7.35 | Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (u... | 32930584 |
| Fibroblast growth factor receptor 4 | IC50 | = | 131.0 | nM | 6.88 | Inhibition of TEL-fused FGFR4 cytoplasmic/juxta membrane domain (unknown origin)... | 29541363 |
| Fibroblast growth factor receptor 4 | IC50 | = | 131.0 | nM | 6.88 | Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphoryl... | 32930584 |
| Fibroblast growth factor receptor 4 | IC50 | = | 301.0 | nM | 6.52 | Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability ... | 32930584 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32930584 | 10.1021/acs.jmedchem.0c01019 | ADMET | 7 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | Fibroblast growth factor receptor 4 | 3 |
| 29541363 | 10.1021/acsmedchemlett.7b00485 | Fibroblast growth factor receptor 4 | 2 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | Huh-7 | 1 |
Data from ChEMBL 36 via Core Engine