Assay Detail
Binding
CHEMBL4255755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shift assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.49 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3973588 | — | — | 1 | 9.15 |
| CHEMBL3896282 | — | — | 1 | 8.96 |
| CHEMBL3940572 | — | — | 1 | 8.92 |
| CHEMBL3908044 | — | — | 1 | 8.89 |
| CHEMBL4279514 | — | — | 1 | 8.66 |
| CHEMBL4294292 | — | — | 1 | 8.49 |
| CHEMBL3933682 | — | — | 1 | 8.20 |
| CHEMBL4287768 | — | — | 1 | 8.19 |
| CHEMBL4279848 | — | — | 1 | 8.13 |
| CHEMBL3954670 | — | — | 1 | 7.96 |
| CHEMBL3923618 | — | — | 1 | 7.89 |
| CHEMBL4068896 | — | — | 1 | 7.85 |
| CHEMBL3971213 | — | — | 1 | 7.80 |
| CHEMBL3962621 | — | — | 1 | 7.77 |
| CHEMBL3946945 | — | — | 1 | 7.68 |
| CHEMBL4282622 | — | — | 1 | 7.64 |
| CHEMBL3970084 | — | — | 1 | 7.57 |
| CHEMBL3893612 | — | — | 1 | 7.48 |
| CHEMBL3982548 | — | — | 1 | 7.38 |
| CHEMBL3977760 | — | — | 1 | 7.35 |
| CHEMBL4277111 | — | — | 1 | 7.24 |
| CHEMBL3939798 | — | — | 1 | 6.85 |
| CHEMBL3893959 | — | — | 1 | 6.76 |
| CHEMBL3936517 | — | — | 1 | 6.52 |
| CHEMBL3911617 | — | — | 1 | 6.18 |
| CHEMBL4282220 | — | — | 1 | 6.10 |
| CHEMBL4288179 | — | — | 1 | 5.36 |
| CHEMBL4278750 | — | — | 1 | 5.28 |
| CHEMBL4292823 | — | — | 1 | 5.02 |
| CHEMBL4286000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3973588 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3896282 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3940572 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3908044 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4279514 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4294292 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3933682 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4287768 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4279848 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3954670 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3923618 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4068896 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3971213 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3962621 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3946945 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4282622 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3970084 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3893612 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3982548 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3977760 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4277111 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3939798 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3893959 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3936517 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3911617 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4282220 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4288179 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4278750 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4292823 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4286000 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4277536 | — | IC50 | > | 10000.0 | nM | - |