Compound Detail
CHEMBL3923618
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Basic Information
| ChEMBL ID | CHEMBL3923618 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BYUZCRJHSPUIHJ-UHFFFAOYSA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
350.3
MW (Da)
3.29
ALogP
4
HBA
1
HBD
75.2
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.89
Kd 1 meas. best 7.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.89 | 7.8867 | 13.0 | 3 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | Kd | 7.55 | 7.55 | 28.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 13.0 | nM | 7.89 | Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKK... | 29541363 |
| Fibroblast growth factor receptor 4 | IC50 | = | 13.0 | nM | 7.89 | Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (u... | 32930584 |
| Fibroblast growth factor receptor 4 | IC50 | = | 13.3 | nM | 7.88 | Biochemical Kinase Assay: Liquid handling and incubation steps were done on an I... | - |
| Fibroblast growth factor receptor 4 | Kd | = | 28.0 | nM | 7.55 | Displacement of PRO-128 from recombinant human N-terminal GST/His6-tagged FGFR4 ... | 29541363 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29541363 | 10.1021/acsmedchemlett.7b00485 | Fibroblast growth factor receptor 4 | 5 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | ADMET | 4 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | Fibroblast growth factor receptor 4 | 3 |
| 29541363 | 10.1021/acsmedchemlett.7b00485 | No relevant target | 2 |
| 30565923 | 10.1021/acs.jmedchem.8b01153 | Fibroblast growth factor receptor 4 | 2 |
| 32930584 | 10.1021/acs.jmedchem.0c01019 | No relevant target | 2 |
Data from ChEMBL 36 via Core Engine