Assay Detail
Binding
CHEMBL4255759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of PRO-128 from recombinant human N-terminal GST/His6-tagged FGFR4 (391 to 802 residues) expressed in baculovirus infected Sf9 insect cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.75 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3971213 | — | — | 1 | 8.30 |
| CHEMBL4279514 | — | — | 1 | 7.70 |
| CHEMBL3923618 | — | — | 1 | 7.55 |
| CHEMBL3982548 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3971213 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL4279514 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL3923618 | — | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL3982548 | — | Kd | = | 35.0 | nM | 7.46 |