Compound Detail
CHEMBL3962621
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Basic Information
| ChEMBL ID | CHEMBL3962621 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GURMECOKUZULQS-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
391.4
MW (Da)
3.04
ALogP
6
HBA
1
HBD
108.2
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.77 | 7.4533 | 17.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 17.0 | nM | 7.77 | Biochemical Kinase Assay: Liquid handling and incubation steps were done on an I... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 17.0 | nM | 7.77 | Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKK... | 29541363 |
| Fibroblast growth factor receptor 4 | IC50 | = | 150.0 | nM | 6.82 | Inhibition of TEL-fused FGFR4 cytoplasmic/juxta membrane domain (unknown origin)... | 29541363 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29541363 | 10.1021/acsmedchemlett.7b00485 | Fibroblast growth factor receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine