Compound Detail
CHEMBL3893959
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Basic Information
| ChEMBL ID | CHEMBL3893959 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZGHWCZVWPOCEJO-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
395.4
MW (Da)
2.56
ALogP
7
HBA
1
HBD
117.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 6.76 | 6.55 | 175.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 175.0 | nM | 6.76 | Biochemical Kinase Assay: Liquid handling and incubation steps were done on an I... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 175.0 | nM | 6.76 | Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKK... | 29541363 |
| Fibroblast growth factor receptor 4 | IC50 | = | 741.0 | nM | 6.13 | Inhibition of TEL-fused FGFR4 cytoplasmic/juxta membrane domain (unknown origin)... | 29541363 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29541363 | 10.1021/acsmedchemlett.7b00485 | Fibroblast growth factor receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine