Assay Detail
Functional
CHEMBL4723345
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Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability by cell proliferation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.05 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284069 | — | — | 1 | 8.17 |
| CHEMBL3973674 | — | — | 1 | 8.05 |
| CHEMBL4742811 | — | — | 1 | 7.36 |
| CHEMBL3972276 | — | — | 1 | 7.14 |
| CHEMBL1852688 | INFIGRATINIB | 4.0 | 1 | 7.07 |
| CHEMBL4279514 | — | — | 1 | 6.58 |
| CHEMBL3966721 | — | — | 1 | 6.58 |
| CHEMBL3916036 | — | — | 1 | 6.32 |
| CHEMBL3929437 | — | — | 1 | 6.14 |
| CHEMBL3904499 | — | — | 1 | - |
| CHEMBL3983290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284069 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3973674 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4742811 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3972276 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1852688 | INFIGRATINIB | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4279514 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL3966721 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL3916036 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL3929437 | — | IC50 | = | 719.0 | nM | 6.14 |
| CHEMBL3904499 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3983290 | — | IC50 | > | 3000.0 | nM | - |