Assay Detail
Binding
CHEMBL4723518
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Binding affinity to sigma-2 receptor (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.23 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777306 | — | — | 1 | 6.82 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.66 |
| CHEMBL100116 | PENTAZOCINE | 4.0 | 1 | 5.73 |
| CHEMBL73234 | CARBETAPENTANE | 4.0 | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777306 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL100116 | PENTAZOCINE | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL73234 | CARBETAPENTANE | Ki | = | 1953.0 | nM | 5.71 |