Assay Detail
Binding
CHEMBL4723814
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.51 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748354 | — | — | 1 | 8.00 |
| CHEMBL4754856 | — | — | 1 | 7.99 |
| CHEMBL4759953 | — | — | 1 | 7.89 |
| CHEMBL4756422 | — | — | 1 | 7.61 |
| CHEMBL4753549 | — | — | 1 | 7.39 |
| CHEMBL4789273 | — | — | 1 | 7.30 |
| CHEMBL4798378 | — | — | 1 | 7.24 |
| CHEMBL4741075 | — | — | 1 | 7.21 |
| CHEMBL4741668 | — | — | 1 | 7.12 |
| CHEMBL4776245 | — | — | 1 | 6.92 |
| CHEMBL4760274 | — | — | 1 | 6.89 |
| CHEMBL4756516 | — | — | 1 | 6.84 |
| CHEMBL4447631 | — | — | 1 | 6.84 |
| CHEMBL4791651 | — | — | 1 | 6.75 |
| CHEMBL4754686 | — | — | 1 | 6.63 |
| CHEMBL4789556 | — | — | 1 | 6.54 |
| CHEMBL4749454 | — | — | 1 | 6.52 |
| CHEMBL4790747 | — | — | 1 | 6.45 |
| CHEMBL4758253 | — | — | 1 | 6.44 |
| CHEMBL4753147 | — | — | 1 | 6.41 |
| CHEMBL4745529 | — | — | 1 | 6.38 |
| CHEMBL4747449 | — | — | 1 | 6.37 |
| CHEMBL4745971 | — | — | 1 | 6.35 |
| CHEMBL4748445 | — | — | 1 | 6.34 |
| CHEMBL4739994 | — | — | 1 | 6.19 |
| CHEMBL4740411 | — | — | 1 | 6.17 |
| CHEMBL4795467 | — | — | 1 | 6.16 |
| CHEMBL4778749 | — | — | 1 | 6.12 |
| CHEMBL4743195 | — | — | 1 | 6.11 |
| CHEMBL4776686 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748354 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4754856 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL4759953 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL4756422 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL4753549 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4789273 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL4798378 | — | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL4741075 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL4741668 | — | IC50 | = | 75.5 | nM | 7.12 |
| CHEMBL4776245 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4760274 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4756516 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4447631 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4791651 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4754686 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL4789556 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4749454 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL4790747 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL4758253 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL4753147 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL4745529 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4747449 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL4745971 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL4748445 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL4739994 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4740411 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL4795467 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL4778749 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4743195 | — | IC50 | = | 784.0 | nM | 6.11 |
| CHEMBL4776686 | — | IC50 | = | 908.0 | nM | 6.04 |
| CHEMBL4763560 | — | IC50 | = | 938.0 | nM | 6.03 |
| CHEMBL4741778 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4757237 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4744166 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4778029 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4760064 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4789489 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4777006 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4744889 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL4793696 | — | IC50 | = | 4390.0 | nM | 5.36 |