Compound Detail
CHEMBL4789556
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CCN(CC)C(=O)/C=C/CN1CCc2cc(Nc3ncc(C)c(-c4cnn(C(C)C)c4)n3)ccc2C1
Basic Information
| ChEMBL ID | CHEMBL4789556 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LEJYYBYZPRLYLD-CMDGGOBGSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
487.6
MW (Da)
4.76
ALogP
7
HBA
1
HBD
79.2
PSA (Ų)
0.44
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL1649049 | IC50 | 6.54 | 6.54 | 287.0 | 1 |
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 6.48 | 6.48 | 329.0 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.18 | 6.18 | 656.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | IC50 | = | 287.0 | nM | 6.54 | Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cel... | 33256400 |
| Tyrosine-protein kinase JAK2 | IC50 | = | 329.0 | nM | 6.48 | Inhibition of JAK2 V617F mutant in human SET-2 cells assessed as reduction in ce... | 33256400 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 656.0 | nM | 6.18 | Inhibition of FLT3 ITD mutant in human MOLM13 cells assessed as reduction in cel... | 33256400 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33256400 | 10.1021/acs.jmedchem.0c01488 | Tyrosine-protein kinase JAK2 | 2 |
| 33256400 | 10.1021/acs.jmedchem.0c01488 | Receptor-type tyrosine-protein kinase FLT3 | 2 |
| 33256400 | 10.1021/acs.jmedchem.0c01488 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine