Assay Detail
Binding
CHEMBL4723822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGGKKK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based radiometry assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.21 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4789273 | — | — | 1 | 7.52 |
| CHEMBL4756422 | — | — | 1 | 7.35 |
| CHEMBL4741075 | — | — | 1 | 7.28 |
| CHEMBL4798378 | — | — | 1 | 7.25 |
| CHEMBL4753549 | — | — | 1 | 7.12 |
| CHEMBL4748354 | — | — | 1 | 7.10 |
| CHEMBL4754856 | — | — | 1 | 7.06 |
| CHEMBL4759953 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4789273 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4756422 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4741075 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4798378 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4753549 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4748354 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4754856 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4759953 | — | IC50 | = | 100.0 | nM | 7.00 |