Assay Detail
ADMET
CHEMBL4724287
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Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total Synthesis of the Antitumor-Antitubercular 2,6'-Bijuglone Natural Product Diospyrin and Its 3,6'-Isomer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.77 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242550 | DIOSPYRIN | — | 1 | 5.24 |
| CHEMBL430853 | RAMENTACEONE | — | 1 | 5.12 |
| CHEMBL4742098 | — | — | 1 | 5.12 |
| CHEMBL4792519 | — | — | 1 | 4.59 |
| CHEMBL242992 | — | — | 1 | 4.59 |
| CHEMBL4748800 | — | — | 1 | 4.50 |
| CHEMBL4757271 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242550 | DIOSPYRIN | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL430853 | RAMENTACEONE | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4742098 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4792519 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL242992 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL4748800 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL4757271 | — | IC50 | = | 61800.0 | nM | 4.21 |