Assay Detail
Binding
CHEMBL4724445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Sprague-Dawley rat brain mitochondrial MAO-B using [14C]-PEA as substrate preincubated for 120 mins by radiochemical method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthetic approaches to unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles and their MAO-B inhibitory activity. A review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.54 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17092 | — | — | 1 | 8.85 |
| CHEMBL17079 | — | — | 1 | 8.43 |
| CHEMBL16781 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17092 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL17079 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL16781 | — | IC50 | = | 4.7 | nM | 8.33 |