Assay Detail
Binding
CHEMBL4724650
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Inhibition of JNK3alpha1 (unknown origin) using ATF2 as substrate after 22 mins in presence of ATP by HTRF assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.16 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4753310 | — | — | 1 | 8.10 |
| CHEMBL4784095 | — | — | 1 | 7.92 |
| CHEMBL4744992 | — | — | 1 | 7.62 |
| CHEMBL4778645 | — | — | 1 | 7.48 |
| CHEMBL4753641 | — | — | 1 | 7.46 |
| CHEMBL4754584 | — | — | 1 | 7.41 |
| CHEMBL4758113 | — | — | 1 | 7.35 |
| CHEMBL4783382 | — | — | 1 | 7.30 |
| CHEMBL4762965 | — | — | 1 | 7.30 |
| CHEMBL4754908 | — | — | 1 | 7.28 |
| CHEMBL4749547 | — | — | 1 | 7.28 |
| CHEMBL4784092 | — | — | 1 | 7.17 |
| CHEMBL4755895 | — | — | 1 | 7.15 |
| CHEMBL4793809 | — | — | 1 | 7.10 |
| CHEMBL4759538 | — | — | 1 | 7.08 |
| CHEMBL4799926 | — | — | 1 | 7.08 |
| CHEMBL4798047 | — | — | 1 | 7.07 |
| CHEMBL4745961 | — | — | 1 | 7.07 |
| CHEMBL4757583 | — | — | 1 | 6.93 |
| CHEMBL4758690 | — | — | 1 | 6.88 |
| CHEMBL4754031 | — | — | 1 | 6.85 |
| CHEMBL4788258 | — | — | 1 | 6.73 |
| CHEMBL4777114 | — | — | 1 | 6.70 |
| CHEMBL4753218 | — | — | 1 | 6.65 |
| CHEMBL4744126 | — | — | 1 | 6.10 |
| CHEMBL4791169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4753310 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4784095 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4744992 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4778645 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4753641 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4754584 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4758113 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4783382 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4762965 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4754908 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4749547 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4784092 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4755895 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4793809 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4759538 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4799926 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4798047 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4745961 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4757583 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4758690 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4754031 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4788258 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4777114 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4753218 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL4744126 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4791169 | — | IC50 | > | 10000.0 | nM | - |