Assay Detail
Functional
CHEMBL4724691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of vorinostat-induced reactivation of latent HIV-1 infected in human Jurkat 2C4 cells assessed as increase in HIV-1 transcription incubated for 24 hrs in presence of vorinostat by Steady-Glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | 2C4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.40 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279433 | L-778123 FREE BASE | 1.0 | 1 | 6.77 |
| CHEMBL4758112 | — | — | 1 | 6.47 |
| CHEMBL4781419 | — | — | 1 | 5.96 |
| CHEMBL4759194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279433 | L-778123 FREE BASE | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4758112 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4781419 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4759194 | — | EC50 | > | 8000.0 | nM | - |