Assay Detail
ADMET
CHEMBL4724765
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Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.04 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.84 |
| CHEMBL4780826 | — | — | 1 | 5.83 |
| CHEMBL4751811 | — | — | 1 | 5.78 |
| CHEMBL4785276 | — | — | 1 | 5.75 |
| CHEMBL1824449 | — | — | 1 | 5.52 |
| CHEMBL4747451 | — | — | 1 | 5.43 |
| CHEMBL4759271 | — | — | 1 | 5.40 |
| CHEMBL4750321 | — | — | 1 | 5.35 |
| CHEMBL4783797 | — | — | 1 | 5.35 |
| CHEMBL4781248 | — | — | 1 | 5.32 |
| CHEMBL4751257 | — | — | 1 | 5.28 |
| CHEMBL4751007 | — | — | 1 | 5.28 |
| CHEMBL4776655 | — | — | 1 | 5.26 |
| CHEMBL4749901 | — | — | 1 | 5.07 |
| CHEMBL4757745 | — | — | 1 | 5.02 |
| CHEMBL4743520 | — | — | 1 | 4.97 |
| CHEMBL4789365 | — | — | 1 | 4.96 |
| CHEMBL4753386 | — | — | 1 | 4.96 |
| CHEMBL4758495 | — | — | 1 | 4.90 |
| CHEMBL4759412 | — | — | 1 | 4.56 |
| CHEMBL4785100 | — | — | 1 | 4.55 |
| CHEMBL4788690 | — | — | 1 | 4.32 |
| CHEMBL4780666 | — | — | 1 | 4.28 |
| CHEMBL4754279 | — | — | 1 | 4.26 |
| CHEMBL4752262 | — | — | 1 | 4.21 |
| CHEMBL4747010 | — | — | 1 | 4.20 |
| CHEMBL4757516 | — | — | 1 | 4.17 |
| CHEMBL4799082 | — | — | 1 | 4.13 |
| CHEMBL4746538 | — | — | 1 | 4.09 |
| CHEMBL4794155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL4780826 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4751811 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4785276 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL1824449 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4747451 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4759271 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4750321 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL4783797 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL4781248 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL4751007 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL4751257 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL4776655 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL4749901 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL4757745 | — | IC50 | = | 9490.0 | nM | 5.02 |
| CHEMBL4743520 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4789365 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4753386 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4758495 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4759412 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL4785100 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL4788690 | — | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL4780666 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL4754279 | — | IC50 | = | 55100.0 | nM | 4.26 |
| CHEMBL4752262 | — | IC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL4747010 | — | IC50 | = | 62700.0 | nM | 4.20 |
| CHEMBL4757516 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL4799082 | — | IC50 | = | 73600.0 | nM | 4.13 |
| CHEMBL4746538 | — | IC50 | = | 81400.0 | nM | 4.09 |
| CHEMBL4757611 | — | IC50 | = | 213000.0 | nM | - |
| CHEMBL4757453 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4794593 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL4761755 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL532994 | — | IC50 | = | 4980000.0 | nM | - |
| CHEMBL4800507 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL4762822 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL4741232 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL4744748 | — | IC50 | = | 249000.0 | nM | - |
| CHEMBL4791436 | — | IC50 | = | 155000.0 | nM | - |
| CHEMBL4764680 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL4794155 | — | IC50 | = | 150000.0 | nM | - |