Assay Detail
Binding
CHEMBL4725117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human S1P5 receptor expressed in Chem-1 cell membrane by 33P-SIP binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Chem-1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Potent Selective Orally Active S1P5 Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.91 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787458 | — | — | 1 | 9.52 |
| CHEMBL4798593 | — | — | 1 | 8.85 |
| CHEMBL4748198 | — | — | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787458 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4798593 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4748198 | — | Ki | = | 4.4 | nM | 8.36 |