Assay Detail
Binding
CHEMBL4725689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4B by scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in the Development of Phosphodiesterase-4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.74 | 10.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 10.39 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 9.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 0.041 | nM | 10.39 |
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 0.84 | nM | 9.08 |