Assay Detail
Binding
CHEMBL4725692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NH2-terminal His6-tagged PDE4B catalytic domain (unknown origin) using Cyclic AMP as substrate incubated for 10 mins followed by substrate addition and measured after 45 mins by luminescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in the Development of Phosphodiesterase-4 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096812 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096812 | — | IC50 | = | 5.0 | nM | 8.30 |