Assay Detail
Functional
CHEMBL4725927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 in presence of 10% FBS
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 8.64 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744182 | — | — | 1 | 9.52 |
| CHEMBL4760026 | — | — | 1 | 9.22 |
| CHEMBL4751455 | — | — | 1 | 9.15 |
| CHEMBL4786078 | — | — | 1 | 9.15 |
| CHEMBL4755951 | — | — | 1 | 9.15 |
| CHEMBL4748499 | — | — | 1 | 9.15 |
| CHEMBL4745479 | — | — | 1 | 9.10 |
| CHEMBL4786799 | — | — | 1 | 9.05 |
| CHEMBL4779601 | — | — | 1 | 9.00 |
| CHEMBL4786092 | — | — | 1 | 9.00 |
| CHEMBL4750708 | — | — | 1 | 8.92 |
| CHEMBL4795180 | — | — | 1 | 8.92 |
| CHEMBL4740178 | — | — | 1 | 8.89 |
| CHEMBL4760280 | — | — | 1 | 8.89 |
| CHEMBL4745638 | — | — | 1 | 8.85 |
| CHEMBL4788865 | — | — | 1 | 8.85 |
| CHEMBL4745227 | — | — | 1 | 8.82 |
| CHEMBL4782946 | — | — | 1 | 8.70 |
| CHEMBL4759219 | — | — | 1 | 8.70 |
| CHEMBL4750254 | — | — | 1 | 8.15 |
| CHEMBL4750918 | — | — | 1 | 8.15 |
| CHEMBL4754986 | — | — | 1 | 8.10 |
| CHEMBL4762216 | — | — | 1 | 8.10 |
| CHEMBL4760806 | — | — | 1 | 7.96 |
| CHEMBL4782667 | — | — | 1 | 7.85 |
| CHEMBL4754233 | — | — | 1 | 7.70 |
| CHEMBL4745112 | — | — | 1 | 7.68 |
| CHEMBL4786541 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744182 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4760026 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4751455 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4786078 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4755951 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4748499 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4745479 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4786799 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4779601 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4786092 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4750708 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4795180 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4740178 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4760280 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4745638 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4788865 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4745227 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4782946 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4759219 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4750254 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4750918 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4754986 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4762216 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4760806 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4782667 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4754233 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4745112 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4786541 | — | EC50 | = | 60.0 | nM | 7.22 |