Assay Detail
Functional
CHEMBL4725928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring G140S/Q148H double mutant in presence of 10% FBS
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.48 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4795180 | — | — | 1 | 8.85 |
| CHEMBL4786078 | — | — | 1 | 8.52 |
| CHEMBL4744182 | — | — | 1 | 8.30 |
| CHEMBL4745479 | — | — | 1 | 8.22 |
| CHEMBL4750708 | — | — | 1 | 8.10 |
| CHEMBL4745227 | — | — | 1 | 8.10 |
| CHEMBL4786799 | — | — | 1 | 8.10 |
| CHEMBL4779601 | — | — | 1 | 8.00 |
| CHEMBL4760026 | — | — | 1 | 7.92 |
| CHEMBL4745638 | — | — | 1 | 7.85 |
| CHEMBL4748499 | — | — | 1 | 7.77 |
| CHEMBL4788865 | — | — | 1 | 7.50 |
| CHEMBL4751455 | — | — | 1 | 7.43 |
| CHEMBL4759219 | — | — | 1 | 7.41 |
| CHEMBL4782946 | — | — | 1 | 7.03 |
| CHEMBL4750254 | — | — | 1 | 6.89 |
| CHEMBL4782667 | — | — | 1 | 6.44 |
| CHEMBL4755951 | — | — | 1 | 6.44 |
| CHEMBL4740178 | — | — | 1 | 6.25 |
| CHEMBL4786092 | — | — | 1 | 6.15 |
| CHEMBL4760280 | — | — | 1 | 5.88 |
| CHEMBL4745112 | — | — | 1 | - |
| CHEMBL4750918 | — | — | 1 | - |
| CHEMBL4754986 | — | — | 1 | - |
| CHEMBL4786541 | — | — | 1 | - |
| CHEMBL4760806 | — | — | 1 | - |
| CHEMBL4754233 | — | — | 1 | - |
| CHEMBL4762216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4795180 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4786078 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4744182 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4745479 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4750708 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4745227 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4786799 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4779601 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4760026 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4745638 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4748499 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4788865 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4751455 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4759219 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4782946 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4750254 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4782667 | — | EC50 | = | 361.0 | nM | 6.44 |
| CHEMBL4755951 | — | EC50 | = | 363.0 | nM | 6.44 |
| CHEMBL4740178 | — | EC50 | = | 558.0 | nM | 6.25 |
| CHEMBL4786092 | — | EC50 | = | 714.0 | nM | 6.15 |
| CHEMBL4760280 | — | EC50 | = | 1325.0 | nM | 5.88 |
| CHEMBL4745112 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL4750918 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL4754986 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL4786541 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL4760806 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL4754233 | — | EC50 | > | 8000.0 | nM | - |
| CHEMBL4762216 | — | EC50 | > | 8000.0 | nM | - |