Assay Detail
Binding
CHEMBL4725977
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Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.68 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790836 | — | — | 1 | 9.20 |
| CHEMBL4760897 | — | — | 1 | 8.85 |
| CHEMBL4781596 | — | — | 1 | 8.82 |
| CHEMBL4784510 | BMS-986235 | 1.0 | 1 | 8.47 |
| CHEMBL4762030 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790836 | — | EC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4760897 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4781596 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4784510 | BMS-986235 | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4762030 | — | EC50 | = | 8.5 | nM | 8.07 |