Assay Detail
ADMET
CHEMBL4726178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin) expressed in baculovirus system using fluorescein labeled PDGFR-tide substrate peptide preincubated for 60 mins followed by ATP addition and measured after 60 mins by IMAP assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of quinoline-based irreversible BTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.45 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4779297 | — | — | 1 | 8.42 |
| CHEMBL4791702 | — | — | 1 | 8.20 |
| CHEMBL4798086 | — | — | 1 | 7.96 |
| CHEMBL4794213 | — | — | 1 | 7.92 |
| CHEMBL4763873 | — | — | 1 | 7.89 |
| CHEMBL4744536 | — | — | 1 | 7.80 |
| CHEMBL4759528 | — | — | 1 | 7.62 |
| CHEMBL4755977 | — | — | 1 | 7.48 |
| CHEMBL4796130 | — | — | 1 | 7.26 |
| CHEMBL4792062 | — | — | 1 | 7.09 |
| CHEMBL4745935 | — | — | 1 | 6.80 |
| CHEMBL4752700 | — | — | 1 | 6.70 |
| CHEMBL4756092 | — | — | 1 | 6.63 |
| CHEMBL4787517 | — | — | 1 | 6.56 |
| CHEMBL4800082 | — | — | 1 | - |
| CHEMBL4743222 | — | — | 1 | - |
| CHEMBL4791135 | — | — | 1 | - |
| CHEMBL4782725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4779297 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4791702 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4798086 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4794213 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4763873 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4744536 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4759528 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4755977 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4796130 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4792062 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4745935 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4752700 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4756092 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4787517 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4800082 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4743222 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4791135 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4782725 | — | IC50 | > | 1000.0 | nM | - |