Assay Detail
Binding
CHEMBL4726199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using tyrosine-6 peptide as substrate preincubated for 1 hr in presence of ATP by Z'-LYTE assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of quinoline-based irreversible BTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.78 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 7.50 |
| CHEMBL4755977 | — | — | 1 | 6.76 |
| CHEMBL4752700 | — | — | 1 | 6.08 |
| CHEMBL4782725 | — | — | 1 | - |
| CHEMBL3707348 | ACALABRUTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4755977 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4752700 | — | IC50 | = | 838.0 | nM | 6.08 |
| CHEMBL4782725 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3707348 | ACALABRUTINIB | IC50 | > | 1000.0 | nM | - |